PUBLICATIONS
de Araujo CV, Denorme F, Stephens WZ, Li Q, Cody MJ, Crandell JL, Petrey AC, Queisser KA, Rustad JL, Evangelista JL, Kay MS, Schiffman JD, Campbell RA, Yost CC.(2023)
Front Immunol. 13:1046574.
Symmetric and asymmetric receptor conformation continuum induced by a new insulin
Xiong X, Blakely A, Kim JH, Menting JG, Schäfer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun Ü, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH. (2022)
Nat Chem Biol. 2022 May;18(5):511-519.
Kim SJ, Yao Z, Marsh MC, Eckert DM, Kay MS, Lyakisheva A, Pasic M, Bansal A, Birnboim C, Jha P, Galipeau Y, Langlois MA, Delgado JC, Elgort MG, Campbell RA, Middleton EA, Stagljar I, Owen SC. (2022)
Nat Commun. 13(1):3716.
Improved Handling of Peptide Segments Using Side Chain-Based "Helping Hand" Solubilizing Tools
Jacobsen MT, Spaltenstein P, Giesler RJ, Chou DH, Kay MS. (2022)
Methods Mol Biol. 2530:81-107.
Charbonneau AA, Eckert DM, Gauvin CC, Lintner NG, Lawrence CM. (2021)
Biomolecules. (12):1852.
Erickson PW, Fulcher JM, Spaltenstein P, Kay MS. (2021)
Bioconjug Chem. 32(10):2233-2244.
A glutamic acid-based traceless linker to address challenging chemical protein syntheses
Giesler RJ, Spaltenstein P, Jacobsen MT, Xu W, Maqueda M, Kay MS. (2021)
Org Biomol Chem. 19(40):8821-8829.
Diarrheal pathogens trigger rapid evolution of the guanylate cyclase-C signaling axis in bats
Carey CM, Apple SE, Hilbert ZA, Kay MS, Elde NC. (2021)
Cell Host Microbe. 29(9):1342-1350.
Enhancing native chemical ligation for challenging chemical protein syntheses
Giesler, R. J., Erickson, P.W., Kay, M.S. (2020)
Curr Opin Chem Biol, 58: 37-44
Khan D, Lee D, Gulten G, Aggarwal A, Wofford J, Krieger I, Tripathi A, Patrick JW, Eckert DM, Laganowsky A, Sacchettini J, Lindahl P, Bankaitis VA. (2020)
Elife. 9:e57081.
Prevention and Treatment of SHIVAD8 Infection in Rhesus Macaques by a Potent D-peptide HIV Entry Inhibitor
Nishimura, Y., Francis, J.N., Donau, O.K., Jesteadt, E., Sadjadpour, R., Smith, A.R., Seamen, M.S., Welch, B.D., Martin, M.A., Kay, M.S. (2020)
PNAS, 117: 22436-42
Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate
Ladinsky, M.S., Gnanapragasam, P.N., Yang, Z., West, A.P., Kay, M.S., Bjorkman, P.J. (2020)
eLife, Jul 22: e58411
Chemical synthesis of Shiga toxin subunit B using a next-generation traceless “helping hand” solubilizing tag
Fulcher, J.M., Petersen, M.E., Giesler, R.J., Cruz, Z.S., Eckert, D.M., Francis, J.N., Kawamoto, E.M., Jacobsen, M.T., Kay, M.S. (2019)
Org Biomol Chem, 17: 10237-44
PKR activation by noncanonical ligands: a 5'-triphosphate requirement versus antisense contamination
Safran SA, Eckert DM, Leslie EA, Bass BL. (2019)
RNA. (9):1192-1201.
Characterization of resistance to a potent D-peptide HIV entry inhibitor
Smith, A.R., Weinstock, M.R., Siglin, A.E., Whitby, F.G., Francis, J.N., Hill, C.P., Eckert, D.M., Root, M.J., Kay, M.S. (2019)
Retrovirology, 16: 28
Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases
Han, H., Fulcher, J.M., Dandey, V.P., Iwasa, J.H., Sundquist, W.I., Kay, M.S., Shen, P.S., Hill, C.P. (2019)
eLife, June 11: e44071
Synthesis of hydrophobic insulin-based peptides using a helping hand strategy
Disotuar, M.M., Petersen, M.E., Nogueira, J.M., Kay, M.S., Chou, D.H. (2019)
Org Biomol Chem, 17: 1703-08
Pharmacokinetic and chemical synthesis optimization of a potent D-peptide HIV entry inhibitor suitable for extended-release delivery
Redman, J.S., Francis, J.N., Marquardt, R., Papac, D., Mueller, A.L., Eckert, D.M., Welch, B.D., Kay, M.S. (2018)
Mol Pharm, 15: 1169-79.
Aligator: A computational tool for optimizing total chemical synthesis of large proteins
Jacobsen, M.T., Erickson, P.W., Kay, M.S. (2017)
Bioorg Med Chem, 25: 4946-52.
A helping hand to overcome solubility challenges in chemical protein synthesis
Jacobsen, M.T., Petersen, M.E., Ye, X., Galibert, M., Lorimer, G.H., Aucagne, V., Kay, M.S. (2016)
J Am Chem Soc, 138: 11775-82.
Synthesis of tumor necrosis factor α for use as a mirror-image phage display target
Petersen, M.E., Jacobsen, M.T., Kay, M.S. (2016)
Org Biomol Chem, 14: 5298-303.
Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets
Clinton, T.R., Weinstock, M.T., Jacobsen, M.T., Szabo-Fresnais, N., Pandya, M.J., Whitby, F.G., Herbert, A.S., Prugar, L.I., McKinnon, R., Hill, C.P., Welch, B.D., Dye, J.M., Eckert, D.M., Kay, M.S. (2015)
Protein Sci, 24: 446-63.
2016 Protein Science Best Paper Award Winner
Synthesis and folding of a mirror-image enzyme reveals ambidextrous chaperone activity
Weinstock, M.T., Jacobsen, M.T. and Kay, M.S. (2014)
Proc Natl Acad Sci USA, 111: 11679-84.
Virion stiffness regulates immature HIV-1 entry
Pang, H.B., Hevroni, L., Kol, N., Eckert, D.M., Tsvitov, M., Kay, M.S., and Rousso, I. (2013)
Retrovirol, 10: 4.
Design of a modular tetrameric scaffold for the synthesis of membrane-localized D-peptide inhibitors of HIV-1 entry
Francis, J.N., Redman, J.S., Eckert, D.M. and Kay, M.S. (2012)
Bioconjugate Chem, 23: 1252-8.
Protease-resistant peptide design – empowering nature’s fragile warriors against HIV
Weinstock, M.T., Francis, J.N., Redman, J.S., and Kay, M.S. (2012)
Peptide Sci, 98: 431-42.
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes
Koirala, S., Bui, H.T., Schubert, H.L., Eckert, D.M., Hill, C.P., Kay, M.S. and Shaw, J.M. (2010)
J Cell Biol, 191: 1127-39.
Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance
Welch, B.D., Francis, J.N., Redman, J.S., Paul, S., Weinstock, M.T., Reeves, J.D., Lie, Y.S., Whitby F.G., Eckert, D.M., Hill, C.P., Root, M.J., and Kay, M.S. (2010)
J Virol, 84: 11235-44.
Stalking influenza
Eckert, D.M. and Kay, M.S. (2010)
Proc Natl Acad Sci USA, 107: 13563-4.
Characterization of the steric defense of the HIV-1 gp41 N-trimer region
Eckert, D.M., Shi, Y., Kim, S., Welch, B.D., Kang, E., Poff, E.S., and Kay, M.S. (2008)
Protein Sci, 17: 2091-100.
Peptide mimic of the HIV envelope gp120-gp41 interface
Kim, S., Pang, H.B., and Kay M.S. (2008)
J Mol Biol, 376: 786-97.
Potent D-peptide inhibitors of HIV-1 entry
Welch, B.W., VanDemark, A.P., Hill, C.P., and Kay, M.S. (2007)
Proc Natl Acad Sci USA, 104: 16828-33.
Silent, but deadly—eliminating reservoirs of latent HIV
Kay, M.S. (2003)
Trends Biotechnol, 21: 420-3.
Protein design of an HIV-1 entry inhibitor
Root, M.J., Kay, M.S., and Kim, P.S. (2001)
Science, 291: 884-8.
Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region
Eckert, D.M. and Kim, P.S. (2001)
Proc Natl Acad Sci USA, 98: 11187-92.
Mechanisms of viral membrane fusion and its inhibition
Eckert, D.M. and Kim, P.S. (2001)
Annu Rev Biochem, 70: 777-810.
Inhibiting HIV-1 entry: Discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket
Eckert, D.M., Malashkevich, V.N., Hong, L.H., Carr, P.A., and Kim, P.S. (1999)
Cell, 99: 103-15.
Loquacious-PD facilitates Drosophila Dicer-2 cleavage through interactions with the helicase domain and dsRNA
Trettin, K.D., Sinha, N.K., Eckert, D.M., Apple, S.E., Bass, B.L. (2017)
Proc Natl Acad Sci USA, 114: E7939-48.
Construction of functional monomeric Type 2 Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase
Neti, S.S., Eckert, D.M., Poulter, C.D. (2016)
Biochemistry, 55: 4229-38.
A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation
Zhao, H., Ghirlando, R., Alfonso, C., Arisaka, F., Attali, I., Bain, D.L., Bakhtina, M.M., Becker, D.F., Bedwell, G.J., Bekdemir, A., Besong, T.M.D., Birck, C., 12, Brautigam, C.A., Brennerman, W., Byron, O., Bzowska, A., Chaires, J.B., Chaton, C.T., Cölfen, H., Connaghan, K.D., Crowley, K.A., Curth, U., Daviter, T., Dean, W.L., Díez, A.I., Ebel, C., Eckert, D.M., Eisele, L.E., Eisenstein, E., England, P., Escalante, C., Fagan, J.A., Fairman, R., Finn, R.M., Fischle, W., García de la Torre, J., Gor, J., Gustafsson, H., Hall, D., Harding, S.E., Hernández Cifre, J.G., Herr, A.B., Howell, E.E., Isaac, R.S., Jao, S., Jose, D., Kim, S., Kokona, B., Kornblatt, J.A., Kosek, D., Krayukhina, E., Krzizike, D., Kusznir, E.A., Kwon, H., Larson, A., Laue, T.M., LeRoy, A., Leech, A.P., Lilie, H., Luger, K., Luque-Ortega, J.R., Ma, J., May, C.A., Maynard, E.L., Modrak-Wojcik, A., Mok, Y., Mücke, N., Nagel-Steger, L., Narlikar, G.J., Noda, M., Nourse, A., Obsil, T., Park, C.K., Park, J., Pawelek, P.D., Perdue, E.E., Perkins, S.J., Perugini, M.A., Peterson, C.L., Peverelli, M.G., Piszczek, G., Prag, G., Prevelige, P.E., Raynal, B.D.E., Rezabkova, L., Richter, K., Ringel, A.E., Rosenberg, R., Rowe, A.J., Rufer, A.C., Scott, D.J., Seravalli, J.G., Solovyova, A.S., Song, R., Staunton, D., Stoddard, C., Stott, K., Strauss, H.M., Streicher, W.W., Sumida, J.P., Swygert, S.G., Szczepanowski, R.H., Tessmer, I., Toth IV, R.T., Tripathy, A., Uchiyama, S., Uebel, S.F.W., Unzai, S., Vitlin Gruber, A., von Hippel, P.H., Wandrey, C., Wang, S., Weitzel, S.E., Wielgus-Kutrowska, B., Wolberger, C., Wolff, M., Wright, E., Wu, Y., Wubben, J.M., Schuck, P.* (2015)
PLoS One, 10(5), e0126420.
A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis
Ren, J., Pei-Chen Lin, C., Pathak, M.C., Temple, B.R., Nile, A.H., Mousley, C.J., Duncan, M.C., Eckert, D.M., Leiker, T.J., Ivanova, P.T., Myers, D.S., Murphy, R.C., Brown, H.A.,Verdaasdonk, J., Bloom, K.S., Ortlund, E.A., Neiman, A.M., and Bankaitis, V.A. (2014)
Mol Biol Cell, 25: 712-27.
The oligomeric state of the active Vps4 AAA ATPase
Monroe, N., Han, H., Gonciarz, M.D., Eckert, D.M., Karren, M.A., Whitby, F.G., Sundquist, W.I., and Hill, C.P. (2014)
J Mol Biol, 426: 510-25.
Novel preclinical models of topical PrEP pharmacodynamics provide rationale for combination of drugs with complementary properties
Mesquita, P.M., Srinivasan, P., Johnson, T.J., Rastogi, R., Evans-Strickfaden, T., Kay, M.S., Buckheit, K.W., Buckheit, R.W. Jr., Smith, J.M., Kiser, P.F. and Herold, B.C. (2013)
Retrovirol, 10: 113.
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
Koirala, S., Guo, Q., Kalia, R., Bui, H.T., Eckert, D.M., Frost, A., and Shaw, J.M. (2013)
Proc Natl Acad Sci USA, 110: E1342-51.
Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function
Stadtmueller, B.M., Kish-Trier, E., Ferrell, K., Petersen, C.N., Robinson, H., Myszka, D.G., Eckert, D.M., Formosa, T., and Hill C.P. (2012)
J Biol Chem, 287: 37371-82.
Revealing the allosterome: systematic identification of metabolite-protein interactions
Orsak, T., Smith, T.L., Eckert, D.M., Lindsley, J.E., and Rutter, J. (2011)
Biochem, 51: 225-32.
One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates
Denton, P.W., Othieno, F., Martinez-Torres, F., Zou, W., Krisko, J.F., Fleming, E., Zein, S., Powell, D.A., Wahl, A, Kwak, Y.T., Welch, B.D., Kay, M.S., Payne, D.A., Gallay, P., Appella, E., Estes, J.D., Lu, M. and Garcia, J.V. (2011)
J Virol, 85: 7582-93.
The effect of purification method on the completeness of the immature HIV-1 Gag shell
Kol N., Tsvitov M., Hevroni L., Wolf S.G., Pang H.B., Kay M.S., and Rousso I. (2010)
J Virol Methods, 169: 244-7.
Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations
Schubert, H.L., Zhai, Q., Sandrin, V., Eckert, D.M., Garcia-Maya, M., Saul, L., Sundquist, W.I., Steiner, R.A., and Hill, C.P. (2010)
Proc Natl Acad Sci USA, 107: 17951-6.
Structural basis for ESCRT-III protein autoinhibition
Bajorek, M., Schubert, H.L., McCullough, J., Langelier, C., Eckert, D.M., Stubblefield, W-M.B., Uter, N.T., Hill, C.P., and Sundquist, W.I. (2009)
Nat Struct Mol Biol, 16: 754-62.
Biochemical and structural studies of yeast Vps4 oligomerization
Gonciarz, M.D., Whitby, F.G., Eckert, D.M., Kieffer, C., Heroux, A., Sundquist, W.I., and Hill, C.P. (2008)
J Mol Biol, 384: 878-95.
Biochemical characterization of a recombinant TRIM5α protein that restricts HIV-1 replication
Langelier, C.R., Sandrin, V., Eckert, D.M., Christensen, D.E., Chandrasekaran, V., Alam, S.L., Aiken, C., Olson, J.C., Kar, A.K., Sodroski, J.G., and Sundquist, W.I. (2008)
J Virol, 82: 11682-94.
A stiffness switch in human immunodeficiency virus
Kol, N., Shi, Y., Tsvitov, M., Barlam, D., Shneck, R.Z., Kay, M.S. & Rousso, I. (2007)
Biophys J, 92: 1777-83.
Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding
Morita, E., Sandrin, V., Alam, S.L., Eckert, D.M., Gygi, S.P. and Sundquist, W.I. (2007)
Cell Host Microbe, 2: 41-53.
RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA
Parker, G.S., Eckert D.M., and Bass, B.L. (2006)
RNA, 12: 807-18.
Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1
Azmi, I., Davies, B., Dimaano, C., Payne, J., Eckert D., Babst, M., and Katzmann, D.J. (2006)
J Cell Biol, 172: 705-17.
Steric accessibility of the HIV-1 gp41 N-trimer region
Hamburger, A.H., Kim, S., Welch, B.D., Kay M.S. (2005)
J Biol Chem, 280: 12567-72.
Inhibiting HIV fusion with a ß-peptide foldamer
Stephens, O.M., Kim, S., Welch, B.D., Hodsdon, M.E., Kay, M.S., Schepartz, A. (2005)
J Am Chem Soc, 127: 13126-7.